InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRF1

Summary

InnateDB Protein

IDBP-244037.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRF1

Protein Name

nuclear respiratory factor 1

Synonyms

ALPHA-PAL;

Species

Homo sapiens

Ensembl Protein

ENSP00000376924

InnateDB Gene

IDBG-40856 (NRF1)

Protein Structure

UniProt Annotation

Function

Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Ubiquitously expressed with strongest expression in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	14 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Biological Process

GO:0001666	response to hypoxia
GO:0006091	generation of precursor metabolites and energy
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007005	mitochondrion organization
GO:0031100	organ regeneration
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051593	response to folic acid
GO:0051602	response to electrical stimulus