InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tpm1

Summary

InnateDB Protein

IDBP-253330.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tpm1

Protein Name

tropomyosin 1, alpha

Synonyms

AA986836; AI854628; alpha-TM; TM2; Tm3; Tmpa; Tpm-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000109315

InnateDB Gene

IDBG-180208 (Tpm1)

Protein Structure

UniProt Annotation

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton

Biological Process

GO:0001701	in utero embryonic development
GO:0003065	positive regulation of heart rate by epinephrine
GO:0034614	cellular response to reactive oxygen species
GO:0045214	sarcomere organization
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0005862	muscle thin filament tropomyosin
GO:0030016	myofibril
GO:0031941	filamentous actin
GO:0032059	bleb
GO:0032587	ruffle membrane