Version 5.4
Mus musculus Protein: Tank
Summary
InnateDB Protein IDBP-255886.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tank
Protein Name TRAF family member-associated Nf-kappa B activator
Synonyms C86182; E430026L09Rik; I-TRAF;
Species Mus musculus
Ensembl Protein ENSMUSP00000108120
InnateDB Gene IDBG-173742 (Tank)
Protein Structure
UniProt Annotation
Function Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 60 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:107676
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70347
PhosphoSite PhosphoSite-P70347
TrEMBL
UniProt Splice Variant
Entrez Gene 21353
UniGene Mm.465720
RefSeq NP_001157543
MGI ID
MGI Symbol Tank
OMIM
CCDS CCDS50592
HPRD
IMGT
EMBL U51907 U59864
GenPept AAB02204 AAC52781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca