Mus musculus Protein: Nod2
InnateDB Protein IDBP-261977.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nod2
Protein Name nucleotide-binding oligomerization domain containing 2
Species Mus musculus
Ensembl Protein ENSMUSP00000105262
InnateDB Gene IDBG-179050 (Nod2)
Protein Structure
UniProt Annotation
Function Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor- interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response. {ECO:0000269PubMed:22607974}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0032500 muramyl dipeptide binding
GO:0042834 peptidoglycan binding
GO:0050700 CARD domain binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0002227 innate immune response in mucosa
GO:0002253 activation of immune response
GO:0002282 microglial cell activation involved in immune response
GO:0002367 cytokine production involved in immune response
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002710 negative regulation of T cell mediated immunity
GO:0002732 positive regulation of dendritic cell cytokine production
GO:0002830 positive regulation of type 2 immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0006963 positive regulation of antibacterial peptide biosynthetic process
GO:0006965 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
GO:0007165 signal transduction
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell proliferation
GO:0009595 detection of biotic stimulus
GO:0016045 detection of bacterium
GO:0031398 positive regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032494 response to peptidoglycan
GO:0032495 response to muramyl dipeptide
GO:0032496 response to lipopolysaccharide
GO:0032498 detection of muramyl dipeptide
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032701 negative regulation of interleukin-18 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0035419 activation of MAPK activity involved in innate immune response
GO:0035556 intracellular signal transduction
GO:0042742 defense response to bacterium
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044130 negative regulation of growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0045089 positive regulation of innate immune response
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766 positive regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0050871 positive regulation of B cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051259 protein oligomerization
GO:0051353 positive regulation of oxidoreductase activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0052033 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071224 cellular response to peptidoglycan
GO:0071225 cellular response to muramyl dipeptide
GO:0071608 macrophage inflammatory protein-1 alpha production
GO:0090022 regulation of neutrophil chemotaxis
GO:2000110 negative regulation of macrophage apoptotic process
GO:2000363 positive regulation of prostaglandin-E synthase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0008180 COP9 signalosome
GO:0009986 cell surface
GO:0031982 vesicle
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2429397
InterPro IPR001315 CARD domain
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00619
Post-translational Modifications
SwissProt Q8K3Z0
PhosphoSite PhosphoSite-
UniProt Splice Variant
Entrez Gene 257632
UniGene Mm.222633
MGI Symbol Nod2
EMBL AC156937 AF520774 AK089390 AY160220 AY160340 AY160341 AY160342 AY160343 AY160344 AY160345 AY160346 AY160347 AY160348 AY160360 AY160361 AY160362 AY160363 AY160364 AY160365 AY160366 AY160367 AY160368 AY160560 AY160561 AY160562 AY160563 AY160564 AY160565 AY160566 AY160567 AY160568 AY160570 AY160571 AY160572 AY160573 AY160574 AY160575 AY160576 AY160577 AY160578 AY160600 AY160601 AY160602 AY160603 AY160604 AY160605 AY160606 AY160607 AY160608 AY160610 AY160611 AY160612 AY160613 AY160614 AY160615 AY160616 AY160617 AY160618 AY160650 AY160651 AY160652 AY160653 AY160654 AY160655 AY160656 AY160657 AY160658 BC044774 DQ289012
GenPept AAH44774 AAM76073 AAN52477 AAN57787 AAN57789 AAN62470 AAN62471 AAN63034 AAN63035 AAN63039 ABC25455 BAE43397