InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppara

Summary

InnateDB Protein

IDBP-262417.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppara

Protein Name

peroxisome proliferator activated receptor alpha

Synonyms

4933429D07Rik; AW742785; Nr1c1; Ppar; PPAR-alpha; PPARalpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105050

InnateDB Gene

IDBG-170640 (Ppara)

Protein Structure

UniProt Annotation

Function

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269PubMed:12955147, ECO:0000269PubMed:19646743, ECO:0000269PubMed:20159955}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407, ECO:0000269PubMed:20159955}.

Disease Associations

Note=Peroxisome proliferators are a diverse group of chemicals that include hypolipidaemic drugs, herbicides and industrial plasticisers. Administration of these chemicals to rodents results in the dramatic proliferation of hepatic peroxisomes as well as liver hyperplasia.

Tissue Specificity

Highly expressed in liver, kidney and heart. Very weakly expressed in brain and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	18 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004872	receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0019902	phosphatase binding
GO:0019904	protein domain specific binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0051525	NFAT protein binding
GO:0097371	MDM2/MDM4 family protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001666	response to hypoxia
GO:0006006	glucose metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0007507	heart development
GO:0008544	epidermis development
GO:0010468	regulation of gene expression
GO:0010871	negative regulation of receptor biosynthetic process
GO:0010887	negative regulation of cholesterol storage
GO:0010891	negative regulation of sequestering of triglyceride
GO:0019217	regulation of fatty acid metabolic process
GO:0030522	intracellular receptor signaling pathway
GO:0032091	negative regulation of protein binding
GO:0032099	negative regulation of appetite
GO:0032868	response to insulin
GO:0032922	circadian regulation of gene expression
GO:0035095	behavioral response to nicotine
GO:0042060	wound healing
GO:0042157	lipoprotein metabolic process
GO:0042752	regulation of circadian rhythm
GO:0043401	steroid hormone mediated signaling pathway
GO:0045722	positive regulation of gluconeogenesis
GO:0045776	negative regulation of blood pressure
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046321	positive regulation of fatty acid oxidation
GO:0070166	enamel mineralization
GO:0072363	regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter
GO:0072366	regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369	regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:1901215	negative regulation of neuron death
GO:2000678	negative regulation of transcription regulatory region DNA binding

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

MGI:104740

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003074 Peroxisome proliferator-activated receptor
IPR003076 Peroxisome proliferator-activated receptor, alpha
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF00105

PRINTS

PR00047
PR00398
PR01288
PR01289

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt