InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo7a

Summary

InnateDB Protein

IDBP-267299.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Myo7a

Protein Name

myosin VIIA

Synonyms

Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102739

InnateDB Gene

IDBG-200041 (Myo7a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0019904	protein domain specific binding
GO:0030507	spectrin binding

Biological Process

GO:0001845	phagolysosome assembly
GO:0006886	intracellular protein transport
GO:0006909	phagocytosis
GO:0007600	sensory perception
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0008152	metabolic process
GO:0030030	cell projection organization
GO:0042472	inner ear morphogenesis
GO:0042490	mechanoreceptor differentiation
GO:0042491	auditory receptor cell differentiation
GO:0048563	post-embryonic organ morphogenesis
GO:0048839	inner ear development
GO:0050953	sensory perception of light stimulus
GO:0051875	pigment granule localization
GO:0051904	pigment granule transport
GO:0060088	auditory receptor cell stereocilium organization
GO:0060113	inner ear receptor cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005902	microvillus
GO:0016324	apical plasma membrane
GO:0016459	myosin complex
GO:0032391	photoreceptor connecting cilium
GO:0032420	stereocilium
GO:0042470	melanosome

Protein Structure and Domains

PDB ID

MGI:104510

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000299 FERM domain
IPR000857 MyTH4 domain
IPR001452 SH3 domain
IPR001609 Myosin head, motor domain
IPR018979 FERM, N-terminal
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029071 Ubiquitin-related domain

PFAM