InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VPS35

Summary

InnateDB Protein

IDBP-29259.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VPS35

Protein Name

vacuolar protein sorting 35 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000299138

InnateDB Gene

IDBG-29257 (VPS35)

Protein Structure

UniProt Annotation

Function

Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). {ECO:0000269PubMed:15247922, ECO:0000269PubMed:23395371}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein.

Disease Associations

Parkinson disease 17 (PARK17) [MIM:614203]: An autosomal dominant, adult-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269PubMed:21763482, ECO:0000269PubMed:21763483, ECO:0000269PubMed:22517097}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	74 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0008219	cell death
GO:0015031	protein transport
GO:0042147	retrograde transport, endosome to Golgi

Cellular Component

GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005829	cytosol
GO:0030904	retromer complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR005378 Vacuolar protein sorting-associated protein 35, Vps35
IPR016024 Armadillo-type fold

PFAM

PF03635

PRINTS

PIRSF

PIRSF009375

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96QK1

PhosphoSite

PhosphoSite-Q96QK1

TrEMBL

UniProt Splice Variant

Entrez Gene

55737

UniGene

Hs.717753

RefSeq

NP_060676

HUGO

HGNC:13487

OMIM

601501

CCDS

CCDS10721

HPRD

06085

IMGT

EMBL

AF175265 AF183418 AF186382 AF191298 AK000395 AK001614 AK023650 AL136888 AL512769 AY007112 BC002414 BC010362 BC093036

GenPept

AAF02778 AAF89953 AAG01989 AAG09687 AAG40619 AAH02414 AAH10362 AAH93036 BAA91137 BAA91790 BAB14626 CAB66822 CAC21686