InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAN2B1

Summary

InnateDB Protein

IDBP-30536.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAN2B1

Protein Name

mannosidase, alpha, class 2B, member 1

Synonyms

LAMAN; MANB;

Species

Homo sapiens

Ensembl Protein

ENSP00000221363

InnateDB Gene

IDBG-30534 (MAN2B1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004559	alpha-mannosidase activity
GO:0008270	zinc ion binding
GO:0015923	mannosidase activity
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006013	mannose metabolic process
GO:0006464	cellular protein modification process
GO:0006517	protein deglycosylation

Cellular Component

GO:0005764	lysosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000602 Glycoside hydrolase family 38, N-terminal domain
IPR011013 Galactose mutarotase-like domain
IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
IPR011682 Glycosyl hydrolase family 38, C-terminal
IPR015341 Glycoside hydrolase, family 38, central domain
IPR028995 Glycoside hydrolase, families 57/38, central domain

PFAM

PF01074
PF07748
PF09261

PRINTS

PIRSF

SMART

SM00872

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00754