Version 5.4
Homo sapiens Protein: CTIF
Summary
InnateDB Protein IDBP-3183.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTIF
Protein Name CBP80/20-dependent translation initiation factor
Synonyms Gm672; KIAA0427;
Species Homo sapiens
Ensembl Protein ENSP00000372459
InnateDB Gene IDBG-3179 (CTIF)
Protein Structure
UniProt Annotation
Function Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269PubMed:19648179}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:19648179}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:19648179}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006446 regulation of translational initiation
Cellular Component
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003890 MIF4G-like, type 3
IPR016024 Armadillo-type fold
PFAM PF02854
PRINTS
PIRSF
SMART SM00543
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43310
PhosphoSite PhosphoSite-O43310
TrEMBL K7EQS5
UniProt Splice Variant
Entrez Gene 9811
UniGene Hs.623413
RefSeq NP_001135869
HUGO HGNC:23925
OMIM 613178
CCDS CCDS45864
HPRD 11083
IMGT
EMBL AB007887 AC022919 AC048380 AC093567 AK095970 BC042146
GenPept AAH42146 BAA24857 BAG53180

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca