Homo sapiens Protein: MUC17 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-32880.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | MUC17 | ||||||||||
Protein Name | mucin 17, cell surface associated | ||||||||||
Synonyms | |||||||||||
Species | Homo sapiens | ||||||||||
Ensembl Protein | ENSP00000302716 | ||||||||||
InnateDB Gene | IDBG-32878 (MUC17) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Probably plays a role in maintaining homeostasis on mucosal surfaces. {ECO:0000269PubMed:17990980}. | ||||||||||
Subcellular Localization | Isoform 1: Cell membrane; Single-pass membrane protein.Isoform 2: Secreted {ECO:0000305}. Cell membrane. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers. {ECO:0000269PubMed:11855812, ECO:0000269PubMed:16737958, ECO:0000269PubMed:9299468}. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | |||||||||||
InterPro |
IPR000082
SEA domain IPR000742 Epidermal growth factor-like domain |
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PFAM |
PF01390
PF00008 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART |
SM00200
SM00181 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q685J3 | ||||||||||
PhosphoSite | PhosphoSite-Q685J3 | ||||||||||
TrEMBL | A1A4F7 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 140453 | ||||||||||
UniGene | Hs.271819 | ||||||||||
RefSeq | NP_001035194 | ||||||||||
HUGO | HGNC:16800 | ||||||||||
OMIM | 608424 | ||||||||||
CCDS | CCDS34711 | ||||||||||
HPRD | 16335 | ||||||||||
IMGT | |||||||||||
EMBL | AC105446 AF016693 AF430017 AJ606307 AJ606308 BC126315 | ||||||||||
GenPept | AAB71686 AAI26316 AAL89737 CAE54435 CAE54436 | ||||||||||