InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAVS

Summary

InnateDB Protein

IDBP-364593.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAVS

Protein Name

mitochondrial antiviral signaling protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000401980

InnateDB Gene

IDBG-49080 (MAVS)

Protein Structure

UniProt Annotation

Function

Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. {ECO:0000269PubMed:16125763, ECO:0000269PubMed:16127453, ECO:0000269PubMed:16153868, ECO:0000269PubMed:16177806, ECO:0000269PubMed:19631370, ECO:0000269PubMed:20451243}.

Subcellular Localization

Mitochondrion outer membrane. Mitochondrion. Peroxisome.

Disease Associations

Tissue Specificity

Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. {ECO:0000269PubMed:16125763, ECO:0000269PubMed:16127453, ECO:0000269PubMed:16153868}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 156 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	156 [view]
Protein-Protein	156 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0050700	CARD domain binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0002218	activation of innate immune response
GO:0002230	positive regulation of defense response to virus by host
GO:0007165	signal transduction
GO:0016032	viral process
GO:0032480	negative regulation of type I interferon production
GO:0032481	positive regulation of type I interferon production
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0032757	positive regulation of interleukin-8 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0033160	positive regulation of protein import into nucleus, translocation
GO:0039529	RIG-I signaling pathway
GO:0042742	defense response to bacterium
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051607	defense response to virus
GO:0060340	positive regulation of type I interferon-mediated signaling pathway
GO:0071360	cellular response to exogenous dsRNA
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production
GO:0071660	positive regulation of IP-10 production
GO:1900063	regulation of peroxisome organization

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane