InnateDB Protein
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IDBP-367851.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RPL15
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Protein Name
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ribosomal protein L15
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Synonyms
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DBA12; EC45; L15; RPL10; RPLY10; RPYL10;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000388529
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InnateDB Gene
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IDBG-22156 (RPL15)
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Protein Structure
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Function |
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Subcellular Localization |
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Disease Associations |
Diamond-Blackfan anemia 12 (DBA12) [MIM:615550]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269PubMed:23812780}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 128 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
128
[view]
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Protein-Protein |
126
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000439
Ribosomal protein L15e
IPR012678
Ribosomal protein L23/L15e core domain
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PFAM |
PF00827
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61313
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PhosphoSite |
PhosphoSite-P61313
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TrEMBL |
Q76N55
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UniProt Splice Variant |
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Entrez Gene |
6138
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UniGene |
Hs.742264
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RefSeq |
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HUGO |
HGNC:10306
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OMIM |
604174
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CCDS |
CCDS2640
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HPRD |
16043
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IMGT |
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EMBL |
AB007173
AB061823
AC124914
AF279903
AF283772
AK290694
AK292000
AY347528
BC014837
BC068198
BC070328
BC071672
BC081565
BT019672
CH471055
L25899
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GenPept |
AAA36583
AAG15591
AAG44837
AAH14837
AAH68198
AAH70328
AAH71672
AAH81565
AAQ24859
AAV38478
BAA25833
BAB79461
BAF83383
BAF84689
EAW64338
EAW64339
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