Mus musculus Protein: Arhgap12
Summary
InnateDB Protein IDBP-369376.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol Arhgap12
Protein Name Rho GTPase activating protein 12
Synonyms 2810011M08Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000138585
InnateDB Gene IDBG-63539 (Arhgap12)
Protein Structure
UniProt Annotation
Function GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0002011 morphogenesis of an epithelial sheet
GO:0006911 phagocytosis, engulfment
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051058 negative regulation of small GTPase mediated signal transduction
Cellular Component
GO:0001891 phagocytic cup
Protein Structure and Domains
PDB ID MGI:1922665
InterPro IPR000198 Rho GTPase-activating protein domain
IPR001202 WW domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR011993 PH-like domain superfamily
IPR035491 ARHGAP12, SH3 domain
IPR036020 WW domain superfamily
IPR036028 SH3-like domain superfamily
PFAM PF00620
PF00397
PF00018
PF07653
PF14604
PF00169
PF16457
PF16652
PRINTS PR00452
PIRSF
SMART SM00324
SM00456
SM00326
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C0D4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 75415
UniGene
RefSeq NP_001034781
MGI ID
MGI Symbol Arhgap12
OMIM
CCDS CCDS37723
HPRD
IMGT
EMBL AK031648 AK077063
GenPept BAC27494 BAC36587