Version 5.4
Homo sapiens Protein: PTCRA
Summary
InnateDB Protein IDBP-379005.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTCRA
Protein Name pre T-cell antigen receptor alpha
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392288
InnateDB Gene IDBG-87386 (PTCRA)
Protein Structure
UniProt Annotation
Function The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow. {ECO:0000269PubMed:8618853, ECO:0000269PubMed:8760805}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ISU1
PhosphoSite PhosphoSite-Q6ISU1
TrEMBL
UniProt Splice Variant
Entrez Gene 171558
UniGene
RefSeq NP_001230099
HUGO HGNC:21290
OMIM 606817
CCDS CCDS59020
HPRD 08435
IMGT
EMBL AF084941 AF101436 AF165312 AL035587 BC069336 BC100771 BC100772 BC100773 BC100774 BC153829 U36759 U38996
GenPept AAB06194 AAB18373 AAC83346 AAF21890 AAF89556 AAH69336 AAI00772 AAI00773 AAI00774 AAI00775 AAI53830 CAI21484

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca