InnateDB Protein
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IDBP-379007.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PTCRA
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Protein Name
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pre T-cell antigen receptor alpha
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000409550
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InnateDB Gene
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IDBG-87386 (PTCRA)
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Protein Structure
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Function |
The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow. {ECO:0000269PubMed:8618853, ECO:0000269PubMed:8760805}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6ISU1
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PhosphoSite |
PhosphoSite-Q6ISU1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
171558
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UniGene |
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RefSeq |
NP_001230098
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HUGO |
HGNC:21290
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OMIM |
606817
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CCDS |
CCDS59019
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HPRD |
08435
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IMGT |
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EMBL |
AF084941
AF101436
AF165312
AL035587
BC069336
BC100771
BC100772
BC100773
BC100774
BC153829
U36759
U38996
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GenPept |
AAB06194
AAB18373
AAC83346
AAF21890
AAF89556
AAH69336
AAI00772
AAI00773
AAI00774
AAI00775
AAI53830
CAI21484
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