InnateDB Protein
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IDBP-383540.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RPL10
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Protein Name
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ribosomal protein L10
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Synonyms
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AUTSX5; DXS648; DXS648E; L10; NOV; QM;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000388600
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InnateDB Gene
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IDBG-91249 (RPL10)
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Protein Structure
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Function |
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Subcellular Localization |
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Disease Associations |
Autism, X-linked 5 (AUTSX5) [MIM:300847]: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. {ECO:0000269PubMed:16940977, ECO:0000269PubMed:21567917}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
95
[view]
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Protein-Protein |
92
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003735
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structural constituent of ribosome
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001197
Ribosomal protein L10e
IPR016180
Ribosomal protein L10e/L16
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PFAM |
PF00252
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PRINTS |
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PIRSF |
PIRSF005590
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-P27635
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TrEMBL |
X1WI28
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UniProt Splice Variant |
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Entrez Gene |
6134
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UniGene |
Hs.739235
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RefSeq |
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HUGO |
HGNC:10298
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OMIM |
312173
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CCDS |
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HPRD |
02421
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IMGT |
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EMBL |
BX936346
BX936347
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GenPept |
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