InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ULBP3

Summary

InnateDB Protein

IDBP-387784.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ULBP3

Protein Name

UL16 binding protein 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000403562

InnateDB Gene

IDBG-97867 (ULBP3)

Protein Structure

UniProt Annotation

Function

Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for KLRK1/NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1. {ECO:0000269PubMed:11777960}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046703	natural killer cell lectin-like receptor binding

Biological Process

GO:0006955	immune response
GO:0016032	viral process
GO:0019882	antigen processing and presentation
GO:0030101	natural killer cell activation
GO:0042267	natural killer cell mediated cytotoxicity
GO:0050776	regulation of immune response