InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELMOD2

Summary

InnateDB Protein

IDBP-38840.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELMOD2

Protein Name

ELMO/CED-12 domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000326342

InnateDB Gene

IDBG-38838 (ELMOD2)

Protein Structure

UniProt Annotation

Function

Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses. {ECO:0000269PubMed:17452337, ECO:0000269PubMed:19966137}.

Subcellular Localization

Disease Associations

Tissue Specificity

Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophages and alveolar walls. {ECO:0000269PubMed:16773575, ECO:0000269PubMed:17452337}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity

Biological Process

GO:0006909	phagocytosis
GO:0043547	positive regulation of GTPase activity
GO:0045087	innate immune response (InnateDB)
GO:0050688	regulation of defense response to virus
GO:0051607	defense response to virus