InnateDB Protein
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IDBP-401501.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mapk8ip3
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Protein Name
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mitogen-activated protein kinase 8 interacting protein 3
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Synonyms
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BB120594; D17Wsu15e; JIP-3; Jip3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; mKIAA1066; Syd2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112955
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InnateDB Gene
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IDBG-149884 (Mapk8ip3)
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Protein Structure
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Function |
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. {ECO:0000269PubMed:10523642, ECO:0000269PubMed:10629060}.
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Subcellular Localization |
Cytoplasm. Golgi apparatus. Cytoplasmic vesicle. Cell projection, growth cone. Note=Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells.
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Disease Associations |
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Tissue Specificity |
Highly expressed throughout many regions of the brain and at lower levels in the heart, liver, lung, testes and kidney. All isoforms have been identified in the brain, isoform 1a is also expressed in the spleen and lung. {ECO:0000269PubMed:10629060, ECO:0000269PubMed:11024282}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
24 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1353598
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InterPro |
IPR011047
Quinonprotein alcohol dehydrogenase-like superfamily
IPR019143
JNK/Rab-associated protein-1, N-terminal
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PFAM |
PF09744
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ESN9
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PhosphoSite |
PhosphoSite-Q9ESN9
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TrEMBL |
Q8CGU7
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UniProt Splice Variant |
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Entrez Gene |
30957
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UniGene |
Mm.488379
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RefSeq |
NP_001156923
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MGI ID |
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MGI Symbol |
Mapk8ip3
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OMIM |
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CCDS |
CCDS50026
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HPRD |
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IMGT |
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EMBL |
AB005662
AB043123
AB043124
AB043125
AB043129
AF178636
AF178637
AF262046
AK039130
AK134797
AY099110
BC004003
BC060603
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GenPept |
AAF26842
AAF26843
AAG36931
AAH04003
AAH60603
AAM45138
BAA85874
BAB16674
BAB16675
BAB16676
BAB16685
BAC30247
BAE22289
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