InnateDB Protein
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IDBP-40862.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NRF1
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Protein Name
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nuclear respiratory factor 1
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Synonyms
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ALPHA-PAL;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000342351
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InnateDB Gene
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IDBG-40856 (NRF1)
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Protein Structure
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Function |
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed with strongest expression in skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
17
[view]
|
Protein-Protein |
14
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000978
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RNA polymerase II core promoter proximal region sequence-specific DNA binding
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GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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Biological Process |
GO:0006091
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generation of precursor metabolites and energy
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GO:0006351
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transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR019525
Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain
IPR019526
Nuclear respiratory factor-1, activation binding domain
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PFAM |
PF10491
PF10492
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q16656
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PhosphoSite |
PhosphoSite-Q16656
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TrEMBL |
C9JP85
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UniProt Splice Variant |
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Entrez Gene |
4899
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UniGene |
Hs.654363
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RefSeq |
NP_001280092
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HUGO |
HGNC:7996
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OMIM |
600879
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CCDS |
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HPRD |
02930
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IMGT |
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EMBL |
AC078846
AC084864
AK290891
AK293351
BC016925
CH236950
CH471070
EU159452
L22454
U02683
U18375
U18376
U18377
U18378
U18379
U18380
U18381
U18382
U18383
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GenPept |
AAA16918
AAA21647
AAA79013
AAH16925
ABV90872
BAF83580
BAG56867
EAL24100
EAW83728
EAW83729
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