InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP1

Summary

InnateDB Protein

IDBP-41965.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP1

Protein Name

Rho GTPase activating protein 1

Synonyms

CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000310491

InnateDB Gene

IDBG-41963 (ARHGAP1)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0009967	positive regulation of signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0043087	regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction