Version 5.4
Homo sapiens Protein: ADARB2
Summary
InnateDB Protein IDBP-45376.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADARB2
Protein Name adenosine deaminase, RNA-specific, B2
Synonyms ADAR3; RED2;
Species Homo sapiens
Ensembl Protein ENSP00000370713
InnateDB Gene IDBG-45374 (ADARB2)
Protein Structure
UniProt Annotation
Function Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Brain specific. Expressed at higher levels in astrocytomas as compared to the normal brain tissue. {ECO:0000269PubMed:10836796, ECO:0000269PubMed:18178553}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004000 adenosine deaminase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR002466 Adenosine deaminase/editase
IPR014720 Double-stranded RNA-binding domain
PFAM PF02137
PF00035
PRINTS
PIRSF
SMART SM00552
SM00358
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NS39
PhosphoSite PhosphoSite-Q9NS39
TrEMBL Q5VW43
UniProt Splice Variant
Entrez Gene 105
UniGene Hs.586663
RefSeq NP_061172
HUGO HGNC:227
OMIM 602065
CCDS CCDS7058
HPRD 09070
IMGT
EMBL AC026224 AF034837 AL392083 AL442069 AL450386 AL513304 BC137477 BC140852
GenPept AAF78094 AAI37478 AAI40853 CAH72171 CAH73405

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca