InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNB2L1

Summary

InnateDB Protein

IDBP-484161.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNB2L1

Protein Name

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

Synonyms

Gnb2-rs1; H12.3; HLC-7; PIG21; RACK1;

Species

Homo sapiens

Ensembl Protein

ENSP00000426909

InnateDB Gene

IDBG-63034 (GNB2L1)

Protein Structure

UniProt Annotation

Function

Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells. Enhances phosphorylation of HIV-1 Nef by PKCs. Promotes migration of breast carcinoma cells by binding to and activating RHOA. {ECO:0000269PubMed:11312657, ECO:0000269PubMed:11884618, ECO:0000269PubMed:12589061, ECO:0000269PubMed:12958311, ECO:0000269PubMed:17108144, ECO:0000269PubMed:17244529, ECO:0000269PubMed:17956333, ECO:0000269PubMed:18088317, ECO:0000269PubMed:18258429, ECO:0000269PubMed:18621736, ECO:0000269PubMed:19423701, ECO:0000269PubMed:19785988, ECO:0000269PubMed:20499158, ECO:0000269PubMed:20541605, ECO:0000269PubMed:20573744, ECO:0000269PubMed:20976005, ECO:0000269PubMed:21212275, ECO:0000269PubMed:21347310, ECO:0000269PubMed:9584165}.

Subcellular Localization

Cell membrane; Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Nucleus. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1. Also associated with the membrane in oncogene-transformed cells. PKC activation induces translocation from the perinuclear region to the cell periphery. In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei. Localized to phagocytic cups following infection by Y.pestis.

Disease Associations

Tissue Specificity

In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. {ECO:0000269PubMed:18621736}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 242 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	242 [view]
Protein-Protein	240 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008200	ion channel inhibitor activity
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0030292	protein tyrosine kinase inhibitor activity
GO:0030971	receptor tyrosine kinase binding
GO:0032947	protein complex scaffold
GO:0042169	SH2 domain binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049	cell cycle
GO:0007369	gastrulation
GO:0010629	negative regulation of gene expression
GO:0016032	viral process
GO:0017148	negative regulation of translation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0030822	positive regulation of cAMP catabolic process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464	positive regulation of protein homooligomerization
GO:0032880	regulation of protein localization
GO:0043065	positive regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0048511	rhythmic process
GO:0050765	negative regulation of phagocytosis
GO:0051302	regulation of cell division
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051726	regulation of cell cycle
GO:0051898	negative regulation of protein kinase B signaling
GO:0051901	positive regulation of mitochondrial depolarization
GO:0061099	negative regulation of protein tyrosine kinase activity
GO:0090003	regulation of establishment of protein localization to plasma membrane
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2000114	regulation of establishment of cell polarity
GO:2000543	positive regulation of gastrulation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0030425	dendrite
GO:0030496	midbody
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome