Version 5.4
Homo sapiens Protein: CLNK
Summary
InnateDB Protein IDBP-484852.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLNK
Protein Name cytokine-dependent hematopoietic cell linker
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000427208
InnateDB Gene IDBG-10035 (CLNK)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0009967 positive regulation of signal transduction
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z7G1
PhosphoSite PhosphoSite-Q7Z7G1
TrEMBL
UniProt Splice Variant
Entrez Gene 116449
UniGene Hs.678910
RefSeq
HUGO HGNC:17438
OMIM 611434
CCDS
HPRD 14720
IMGT
EMBL AB032369 AB110420 AC005599 BC029887
GenPept AAH29887 BAA96241 BAC76765

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca