InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRD

Summary

InnateDB Protein

IDBP-49245.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRD

Protein Name

protein tyrosine phosphatase, receptor type, D

Synonyms

HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA;

Species

Homo sapiens

Ensembl Protein

ENSP00000370593

InnateDB Gene

IDBG-49243 (PTPRD)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0006796	phosphate-containing compound metabolic process
GO:0007157	heterophilic cell-cell adhesion
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0016311	dephosphorylation
GO:0030182	neuron differentiation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0050775	positive regulation of dendrite morphogenesis
GO:0097105	presynaptic membrane assembly

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108
PF07679

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt