Homo sapiens Protein: WNK4 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-51677.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | WNK4 | ||||||||||||||||||||||
Protein Name | WNK lysine deficient protein kinase 4 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000246914 | ||||||||||||||||||||||
InnateDB Gene | IDBG-51675 (WNK4) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. {ECO:0000269PubMed:20525693}. | ||||||||||||||||||||||
Subcellular Localization | Cell junction, tight junction {ECO:0000250}. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | Pseudohypoaldosteronism 2B (PHA2B) [MIM:614491]: An autosomal dominant disorder characterized by hypertension, hyperkalemia, hyperchloremia, mild hyperchloremic metabolic acidosis, and correction of physiologic abnormalities by thiazide diuretics. {ECO:0000269PubMed:11498583}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||
Tissue Specificity | Expressed in kidney, colon and skin. {ECO:0000269PubMed:11571656}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain |
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PFAM |
PF00069
PF07714 PF12202 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q96J92 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q96J92 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 65266 | ||||||||||||||||||||||
UniGene | Hs.105448 | ||||||||||||||||||||||
RefSeq | NP_115763 | ||||||||||||||||||||||
HUGO | HGNC:14544 | ||||||||||||||||||||||
OMIM | 601844 | ||||||||||||||||||||||
CCDS | CCDS11439 | ||||||||||||||||||||||
HPRD | 03505 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF390018 AJ309861 AJ316534 AK096003 AK096052 BC136664 CH471152 EU332870 | ||||||||||||||||||||||
GenPept | AAI36665 AAK91995 ABY87559 BAC04669 BAC04688 CAC32991 CAC48387 EAW60881 EAW60882 | ||||||||||||||||||||||