InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL1RAPL1

Summary

InnateDB Protein

IDBP-53482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1RAPL1

Protein Name

interleukin 1 receptor accessory protein-like 1

Synonyms

IL1R8; IL1RAPL; MRX10; MRX21; MRX34; OPHN4; TIGIRR-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000368278

InnateDB Gene

IDBG-53480 (IL1RAPL1)

Protein Structure

UniProt Annotation

Function

May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons. {ECO:0000269PubMed:12783849, ECO:0000269PubMed:15123616}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12783849}; Single-pass type I membrane protein {ECO:0000269PubMed:12783849}. Cytoplasm {ECO:0000269PubMed:12783849}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=May localize to the cell body and growth cones of dendrite-like processes. {ECO:0000250}.

Disease Associations

Mental retardation, X-linked 21 (MRX21) [MIM:300143]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non- syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269PubMed:10757639, ECO:0000269PubMed:16470793}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver. {ECO:0000269PubMed:10471494, ECO:0000269PubMed:10882729}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0007165	signal transduction
GO:0010975	regulation of neuron projection development
GO:0030182	neuron differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045920	negative regulation of exocytosis
GO:0050775	positive regulation of dendrite morphogenesis
GO:0070588	calcium ion transmembrane transport
GO:0097105	presynaptic membrane assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF01582
PF13676
PF07679
PF00047

PRINTS

PIRSF

SMART

SM00255
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NZN1