Version 5.4
Mus musculus Protein: Smad3
Summary
InnateDB Protein IDBP-539711.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smad3
Protein Name MAD homolog 3 (Drosophila)
Synonyms AU022421; Madh3;
Species Mus musculus
Ensembl Protein ENSMUSP00000116790
InnateDB Gene IDBG-175693 (Smad3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 97 experimentally validated interaction(s) in this database.
They are also associated with 296 interaction(s) predicted by orthology.
Experimentally validated
Total 97 [view]
Protein-Protein 63 [view]
Protein-DNA 33 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 296 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0005518 collagen binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001889 liver development
GO:0001947 heart looping
GO:0002076 osteoblast development
GO:0002520 immune system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0009880 embryonic pattern specification
GO:0016202 regulation of striated muscle tissue development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030878 thyroid gland development
GO:0045668 negative regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048340 paraxial mesoderm morphogenesis
GO:0048589 developmental growth
GO:0048617 embryonic foregut morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050678 regulation of epithelial cell proliferation
GO:0051098 regulation of binding
GO:0060039 pericardium development
GO:0070306 lens fiber cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1201674
InterPro IPR001132 SMAD domain, Dwarfin-type
IPR003619 MAD homology 1, Dwarfin-type
IPR008984 SMAD/FHA domain
IPR013019 MAD homology, MH1
PFAM PF03166
PF03165
PRINTS
PIRSF
SMART SM00524
SM00523
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2CG44
UniProt Splice Variant
Entrez Gene 17127
UniGene Mm.7320
RefSeq
MGI ID
MGI Symbol Smad3
OMIM
CCDS
HPRD
IMGT
EMBL AC158515 CT010509
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca