Version 5.4
Homo sapiens Protein: TBKBP1
Summary
InnateDB Protein IDBP-56120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBKBP1
Protein Name TBK1 binding protein 1
Synonyms ProSAPiP2; SINTBAD;
Species Homo sapiens
Ensembl Protein ENSP00000354777
InnateDB Gene IDBG-56118 (TBKBP1)
Protein Structure
UniProt Annotation
Function Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. {ECO:0000269PubMed:21931631}.
Subcellular Localization
Disease Associations
Tissue Specificity Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus. {ECO:0000269PubMed:17568778}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7MCY6
PhosphoSite PhosphoSite-A7MCY6
TrEMBL J3KS71
UniProt Splice Variant
Entrez Gene 9755
UniGene Hs.94790
RefSeq NP_055541
HUGO HGNC:30140
OMIM 608476
CCDS CCDS45722
HPRD 12239
IMGT
EMBL AB018318 AC015674 BC111418 BC152407 BC167150
GenPept AAI11419 AAI52408 AAI67150 BAA34495

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca