InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NFE2L1

Summary

InnateDB Protein

IDBP-56548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFE2L1

Protein Name

nuclear factor (erythroid-derived 2)-like 1

Synonyms

LCR-F1; NRF1; TCF11;

Species

Homo sapiens

Ensembl Protein

ENSP00000354855

InnateDB Gene

IDBG-56544 (NFE2L1)

Protein Structure

UniProt Annotation

Function

Activates erythroid-specific, globin gene expression.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:16687406}; Single-pass type II membrane protein {ECO:0000269PubMed:16687406}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00978, ECO:0000269PubMed:16687406}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	23 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006783	heme biosynthetic process
GO:0006954	inflammatory response
GO:0009653	anatomical structure morphogenesis
GO:0030218	erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter