InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBLC

Summary

InnateDB Protein

IDBP-56599.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBLC

Protein Name

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

Synonyms

CBL-3; CBL-SL; RNF57;

Species

Homo sapiens

Ensembl Protein

ENSP00000340250

InnateDB Gene

IDBG-56595 (CBLC)

Protein Structure

UniProt Annotation

Function

Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. {ECO:0000269PubMed:10362357, ECO:0000269PubMed:14661060, ECO:0000269PubMed:18753381, ECO:0000269PubMed:20525694, ECO:0000269PubMed:23145173}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10362357}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005154	epidermal growth factor receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0017124	SH3 domain binding
GO:0046872	metal ion binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043407	negative regulation of MAP kinase activity

Cellular Component

GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR001841 Zinc finger, RING-type
IPR003153 Adaptor protein Cbl, N-terminal helical
IPR014741 Adaptor protein Cbl, EF hand-like
IPR014742 Adaptor protein Cbl, SH2-like
IPR018957 Zinc finger, C3HC4 RING-type

PFAM