InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBXW11

Summary

InnateDB Protein

IDBP-57613.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXW11

Protein Name

F-box and WD repeat domain containing 11

Synonyms

BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos;

Species

Homo sapiens

Ensembl Protein

ENSP00000265094

InnateDB Gene

IDBG-57611 (FBXW11)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. Involved in the oxidative stress- induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S- phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269PubMed:10321728, ECO:0000269PubMed:10437795, ECO:0000269PubMed:10644755, ECO:0000269PubMed:10648623, ECO:0000269PubMed:14532120, ECO:0000269PubMed:14603323, ECO:0000269PubMed:15917222, ECO:0000269PubMed:18575781, ECO:0000269PubMed:19730691, ECO:0000269PubMed:19966869, ECO:0000269PubMed:20347421}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	98 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0000278	mitotic cell cycle
GO:0006470	protein dephosphorylation
GO:0016055	Wnt signaling pathway
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031648	protein destabilization
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0042753	positive regulation of circadian rhythm
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045862	positive regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048511	rhythmic process

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR001810 F-box domain
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
IPR021977 D domain of beta-TrCP

PFAM

PF00400
PF00646
PF12937
PF13013
PF12125

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00256
SM01028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt