InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAOA

Summary

InnateDB Protein

IDBP-58308.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAOA

Protein Name

monoamine oxidase A

Synonyms

MAO-A;

Species

Homo sapiens

Ensembl Protein

ENSP00000340684

InnateDB Gene

IDBG-58306 (MAOA)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Subcellular Localization

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Disease Associations

Brunner syndrome (BRUNS) [MIM:300615]: A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. {ECO:0000269PubMed:8211186}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Heart, liver, duodenum, blood vessels and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008131	primary amine oxidase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006576	cellular biogenic amine metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0042135	neurotransmitter catabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042420	dopamine catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR001613 Flavin amine oxidase
IPR002937 Amine oxidase
IPR002938 Monooxygenase, FAD-binding
IPR003953 FAD binding domain
IPR006076 FAD dependent oxidoreductase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00070
PF01593
PF01494
PF00890
PF01266
PF07992

PRINTS

PR00757

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21397