Version 5.4
Homo sapiens Protein: PPFIA2
Summary
InnateDB Protein IDBP-583611.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPFIA2
Protein Name protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000447868
InnateDB Gene IDBG-49741 (PPFIA2)
Protein Structure
UniProt Annotation
Function Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269PubMed:9624153}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:9624153}. Cell surface {ECO:0000269PubMed:9624153}. Note=Colocalizes with PTPRF at the cell surface.
Disease Associations
Tissue Specificity Expressed only in brain. {ECO:0000269PubMed:9624153}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007160 cell-matrix adhesion
Cellular Component
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
PFAM PF07647
PF00536
PRINTS
PIRSF
SMART SM00454
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75334
PhosphoSite PhosphoSite-O75334
TrEMBL F8W1Y8
UniProt Splice Variant
Entrez Gene 8499
UniGene Hs.737278
RefSeq NP_001207404
HUGO HGNC:9246
OMIM 603143
CCDS CCDS55855
HPRD 04392
IMGT
EMBL AC011316 AC069228 AC078920 AC079363 AC079408 AF034799 AK123372 AK126971 AK294505 AK296380 AK299853 BC104912 BC143485
GenPept AAC26100 AAI04913 AAI43486 BAG53897 BAG54412 BAH11792 BAH12335 BAH13149

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca