InnateDB Protein
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IDBP-585998.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATG13
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Protein Name
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ATG13 autophagy related 13 homolog (S. cerevisiae)
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Synonyms
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KIAA0652; PARATARG8;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000431974
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InnateDB Gene
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IDBG-41852 (ATG13)
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Protein Structure
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Function |
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269PubMed:18936157, ECO:0000269PubMed:19211835, ECO:0000269PubMed:19225151, ECO:0000269PubMed:19287211, ECO:0000269PubMed:21795849, ECO:0000269PubMed:21855797}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
47
[view]
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Protein-Protein |
47
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR018731
Autophagy-related protein 13
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PFAM |
PF10033
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75143
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PhosphoSite |
PhosphoSite-O75143
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TrEMBL |
J9JIF6
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UniProt Splice Variant |
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Entrez Gene |
9776
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UniGene |
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RefSeq |
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HUGO |
HGNC:29091
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OMIM |
615088
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CCDS |
CCDS44582
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HPRD |
13809
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IMGT |
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EMBL |
AB014552
AC115088
AC127035
AK023867
AK223603
AK294110
BC001331
BC002378
BC006191
CH471064
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GenPept |
AAH01331
AAH02378
AAH06191
BAA31627
BAB14707
BAD97323
BAG57445
EAW67985
EAW67986
EAW67987
EAW67988
EAW67989
EAW67990
EAW67991
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