Homo sapiens Protein: PDXK
Summary
InnateDB Protein IDBP-595401.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol PDXK
Protein Name pyridoxal kinase
Synonyms C21orf124; C21orf97; HEL-S-1a; PKH; PNK; PRED79;
Species Homo sapiens
Ensembl Protein ENSP00000291565
InnateDB Gene IDBG-115602 (PDXK)
Protein Structure
UniProt Annotation
Function Required for synthesis of pyridoxal-5-phosphate from vitamin B6.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Ubiquitous. Isoform 3 is detected in adult testis and spermatozoa.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0008478 pyridoxal kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0030955 potassium ion binding
GO:0031402 sodium ion binding
GO:0031403 lithium ion binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0008283 cell proliferation
GO:0009443 pyridoxal 5'-phosphate salvage
GO:0016310 phosphorylation
GO:0042816 vitamin B6 metabolic process
GO:0042823 pyridoxal phosphate biosynthetic process
GO:0043312 neutrophil degranulation
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034774 secretory granule lumen
GO:0035580 specific granule lumen
GO:0070062 extracellular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004625 Pyridoxine kinase
IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase
IPR029056 Ribokinase-like
PFAM PF08543
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00764
PhosphoSite PhosphoSite-
TrEMBL V9HWC3
UniProt Splice Variant
Entrez Gene 8566
UniGene
RefSeq NP_003672
HUGO HGNC:8819
OMIM 179020
CCDS CCDS13699
HPRD
IMGT
EMBL AP001752 AY303972 BC000123 BC005825 CH471079 EU794642 U89606
GenPept AAC51233 AAH00123 AAH05825 AAP73047 ACJ13696 BAA95540 EAX09475