Homo sapiens Protein: SPNS1
Summary
InnateDB Protein IDBP-597339.1
Last Modified 2018-06-05 [Report errors or provide feedback]
Gene Symbol SPNS1
Protein Name sphingolipid transporter 1 (putative)
Synonyms HSpin1; LAT; nrs; PP2030; SPIN1; SPINL;
Species Homo sapiens
Ensembl Protein ENSP00000306050
InnateDB Gene IDBG-117800 (SPNS1)
Protein Structure
UniProt Annotation
Function Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death. {ECO:0000250, ECO:0000269PubMed:12815463}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:12815463}; Multi-pass membrane protein {ECO:0000269PubMed:12815463}. Note=Colocalizes with SDHB.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046624 sphingolipid transporter activity
Biological Process
GO:0003376 sphingosine-1-phosphate signaling pathway
GO:0006869 lipid transport
GO:0040011 locomotion
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005765 lysosomal membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031982 vesicle
Protein Structure and Domains
PDB ID
InterPro IPR011701 Major facilitator superfamily
IPR020846 Major facilitator superfamily domain
IPR036259 MFS transporter superfamily
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H2V7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 83985
UniGene
RefSeq NP_001135921
HUGO HGNC:30621
OMIM 612583
CCDS CCDS45453
HPRD
IMGT
EMBL AC109460 AF212371 AF370423 AK095677 AK289787 AL390215 BC006156 BC008325 BC038961 BC047741 BC065235 CH471267
GenPept AAG43830 AAH06156 AAH08325 AAH38961 AAH47741 AAH65235 AAQ15259 BAC04603 BAF82476 CAB99229 EAW52018 EAW52019