InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGAT4C

Summary

InnateDB Protein

IDBP-603330.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGAT4C

Protein Name

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)

Synonyms

GNTIVH; HGNT-IV-H;

Species

Homo sapiens

Ensembl Protein

ENSP00000447253

InnateDB Gene

IDBG-50146 (MGAT4C)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). {ECO:0000250, ECO:0000269PubMed:10962001}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, adrenal gland, testis, liver, brain and fetal brain. Not expressed in pancreas. {ECO:0000269PubMed:10570912}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process