InnateDB Protein
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IDBP-603330.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MGAT4C
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Protein Name
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mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
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Synonyms
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GNTIVH; HGNT-IV-H;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000447253
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InnateDB Gene
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IDBG-50146 (MGAT4C)
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Protein Structure
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Function |
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). {ECO:0000250, ECO:0000269PubMed:10962001}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, adrenal gland, testis, liver, brain and fetal brain. Not expressed in pancreas. {ECO:0000269PubMed:10570912}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0008454
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alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006759
Glycosyl transferase, family 54
IPR010920
Like-Sm (LSM) domain
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF04666
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBM8
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PhosphoSite |
PhosphoSite-Q9UBM8
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TrEMBL |
F8VWY2
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UniProt Splice Variant |
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Entrez Gene |
25834
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UniGene |
Hs.589093
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RefSeq |
XP_005268838
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HUGO |
HGNC:30871
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OMIM |
607385
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CCDS |
CCDS9030
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HPRD |
09575
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IMGT |
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EMBL |
AB024729
AB024730
AB024911
AC010196
AC016993
AC025157
AC079596
AC079865
AC087887
AC093122
AC128681
AC139663
AC139697
AK299253
BC026068
BC064141
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GenPept |
AAH26068
AAH64141
BAA83074
BAA83075
BAA83087
BAG61284
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