InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMED9

Summary

InnateDB Protein

IDBP-60478.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMED9

Protein Name

transmembrane emp24 protein transport domain containing 9

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000330945

InnateDB Gene

IDBG-60476 (TMED9)

Protein Structure

UniProt Annotation

Function

Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. {ECO:0000269PubMed:10852829, ECO:0000269PubMed:14600267, ECO:0000269PubMed:16595549, ECO:0000269PubMed:18287528, ECO:0000269PubMed:19296914}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding

Biological Process

GO:0006810	transport
GO:0007030	Golgi organization
GO:0010638	positive regulation of organelle organization
GO:0048205	COPI coating of Golgi vesicle

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0030140	trans-Golgi network transport vesicle
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070062	extracellular vesicular exosome