InnateDB Protein
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IDBP-60478.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TMED9
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Protein Name
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transmembrane emp24 protein transport domain containing 9
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000330945
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InnateDB Gene
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IDBG-60476 (TMED9)
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Protein Structure
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Function |
Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. {ECO:0000269PubMed:10852829, ECO:0000269PubMed:14600267, ECO:0000269PubMed:16595549, ECO:0000269PubMed:18287528, ECO:0000269PubMed:19296914}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009038
GOLD
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PFAM |
PF01105
PF13897
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BVK6
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PhosphoSite |
PhosphoSite-Q9BVK6
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TrEMBL |
A0A024R7M0
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UniProt Splice Variant |
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Entrez Gene |
54732
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UniGene |
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RefSeq |
NP_059980
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HUGO |
HGNC:24878
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OMIM |
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CCDS |
CCDS4428
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HPRD |
09975
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IMGT |
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EMBL |
AC139795
AF441399
BC001123
CH471195
X90872
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GenPept |
AAH01123
AAL35268
CAA62380
EAW84966
EAW84968
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