InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnq2

Summary

InnateDB Protein

IDBP-626638.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnq2

Protein Name

potassium voltage-gated channel, subfamily Q, member 2

Synonyms

HNSPC; KQT2; Nmf134;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131756

InnateDB Gene

IDBG-213954 (Kcnq2)

Protein Structure

UniProt Annotation

Function

Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. {ECO:0000269PubMed:10854243}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Exclusively expressed in the brain. Expressed in every neuron-containing regions of the central nervous system examined, such as the cerebellum, cerebral cortex, occipital pole, substantia nigra, amygdala, caudate nucleus, hippocampus and thalamus. Also detected in the cochlea.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005251	delayed rectifier potassium channel activity

Biological Process

GO:0006811	ion transport
GO:0019226	transmission of nerve impulse
GO:0034765	regulation of ion transmembrane transport
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0033268	node of Ranvier
GO:0043194	axon initial segment

Protein Structure and Domains

PDB ID

MGI:1309503

InterPro

IPR003091 Potassium channel
IPR003937 Potassium channel, voltage dependent, KCNQ
IPR003947 Potassium channel, voltage dependent, KCNQ2
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain

PFAM

PF00520
PF07885

PRINTS

PR00169
PR01459
PR01461

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z351