InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNE3

Summary

InnateDB Protein

IDBP-64312.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNE3

Protein Name

potassium voltage-gated channel, Isk-related family, member 3

Synonyms

HOKPP; HYPP; MiRP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000310557

InnateDB Gene

IDBG-64310 (KCNE3)

Protein Structure

UniProt Annotation

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Brugada syndrome 6 (BRGDA6) [MIM:613119]: A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO:0000269PubMed:19122847}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Widely expressed with highest levels in kidney and moderate levels in small intestine. {ECO:0000269PubMed:10646604}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005249	voltage-gated potassium channel activity
GO:0015459	potassium channel regulator activity

Biological Process

GO:0006811	ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0043266	regulation of potassium ion transport
GO:0071805	potassium ion transmembrane transport