InnateDB Protein
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IDBP-64312.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KCNE3
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Protein Name
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potassium voltage-gated channel, Isk-related family, member 3
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Synonyms
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HOKPP; HYPP; MiRP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000310557
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InnateDB Gene
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IDBG-64310 (KCNE3)
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Protein Structure
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Function |
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
Brugada syndrome 6 (BRGDA6) [MIM:613119]: A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO:0000269PubMed:19122847}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Widely expressed with highest levels in kidney and moderate levels in small intestine. {ECO:0000269PubMed:10646604}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005249
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voltage-gated potassium channel activity
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GO:0015459
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potassium channel regulator activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000369
Potassium channel, voltage-dependent, beta subunit, KCNE
IPR005426
Potassium channel, voltage-dependent, beta subunit, KCNE3
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PFAM |
PF02060
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PRINTS |
PR00168
PR01606
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y6H6
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PhosphoSite |
PhosphoSite-Q9Y6H6
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TrEMBL |
Q6IAE6
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UniProt Splice Variant |
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Entrez Gene |
10008
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UniGene |
Hs.523899
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RefSeq |
NP_005463
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HUGO |
HGNC:6243
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OMIM |
604433
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CCDS |
CCDS8232
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HPRD |
07256
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IMGT |
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EMBL |
AF076531
AF302494
AK311876
AP001372
BC032235
BC110612
BC113743
CH471076
CR457209
CR936625
DQ192291
DQ192292
DQ784805
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GenPept |
AAD28089
AAG16255
AAI10613
AAI13744
ABB00304
ABB00305
ABQ01240
BAG34817
CAG33490
CAI56768
EAW74938
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