Version 5.4
Bos taurus Protein: IL21
Summary
InnateDB Protein IDBP-681766.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL21
Protein Name Interleukin-21
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016413
InnateDB Gene IDBG-630309 (IL21)
Protein Structure
UniProt Annotation
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T- cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000269PubMed:12969638}.
Disease Associations
Tissue Specificity Expressed in spleen, but not in the brain, heart, kidney, liver, and lung. {ECO:0000269PubMed:12969638}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005134 interleukin-2 receptor binding
Biological Process
GO:0002729 positive regulation of natural killer cell cytokine production
GO:0006955 immune response
GO:0008284 positive regulation of cell proliferation
GO:0030890 positive regulation of B cell proliferation
GO:0032733 positive regulation of interleukin-10 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032825 positive regulation of natural killer cell differentiation
GO:0042102 positive regulation of T cell proliferation
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0048469 cell maturation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR003443 Interleukin-15/Interleukin-21 family
PFAM PF02372
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q76LU5
PhosphoSite PhosphoSite-
TrEMBL F1MZV7
UniProt Splice Variant
Entrez Gene 378475
UniGene Bt.23583
RefSeq NP_942129
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB073021 DAAA02044764
GenPept BAC87747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca