Version 5.4
Bos taurus Protein: FAIM2
Summary
InnateDB Protein IDBP-684078.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAIM2
Protein Name Fas apoptotic inhibitory molecule 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023267
InnateDB Gene IDBG-632463 (FAIM2)
Protein Structure
UniProt Annotation
Function Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0002931 response to ischemia
GO:0006915 apoptotic process
GO:0021549 cerebellum development
GO:0021680 cerebellar Purkinje cell layer development
GO:0021681 cerebellar granular layer development
GO:0021702 cerebellar Purkinje cell differentiation
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR006214 Bax inhibitor 1-related
PFAM PF01027
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1LZ71
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509790
UniGene Bt.34795
RefSeq NP_001068886
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116167
GenPept AAI16168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca