InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIPH

Summary

InnateDB Protein

IDBP-68531.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIPH

Protein Name

lipase, member H

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000296252

InnateDB Gene

IDBG-68529 (LIPH)

Protein Structure

UniProt Annotation

Function

Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269PubMed:12063250, ECO:0000269PubMed:12963729}.

Subcellular Localization

Secreted. Membrane; Peripheral membrane protein.

Disease Associations

Hypotrichosis 7 (HYPT7) [MIM:604379]: A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. {ECO:0000269PubMed:17095700, ECO:0000269PubMed:19167195}. Note=The disease is caused by mutations affecting the gene represented in this entry.Woolly hair autosomal recessive 2 (ARWH2) [MIM:604379]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis. {ECO:0000269PubMed:18830268}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including the stem cell-rich bulge region. {ECO:0000269PubMed:12063250, ECO:0000269PubMed:12213196, ECO:0000269PubMed:12719377, ECO:0000269PubMed:17095700}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0008201	heparin binding
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0016042	lipid catabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000734 Lipase
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00151

PRINTS

PR00821

PIRSF

PIRSF000865

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt