Version 5.4
Bos taurus Protein: PLEKHG5
Summary
InnateDB Protein IDBP-685568.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHG5
Protein Name pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022238
InnateDB Gene IDBG-633823 (PLEKHG5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035767 endothelial cell chemotaxis
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043542 endothelial cell migration
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0030027 lamellipodium
GO:0030139 endocytic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR029071 Ubiquitin-related domain
PFAM PF00621
PF00169
PRINTS
PIRSF
SMART SM00325
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MPJ6
UniProt Splice Variant
Entrez Gene 615910
UniGene Bt.91187
RefSeq XP_002694213
HUGO HGNC:29105
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02043081 DAAA02043082 DAAA02043083
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca