Version 5.4
Bos taurus Protein: SMPD1
Summary
InnateDB Protein IDBP-685973.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMPD1
Protein Name Sphingomyelin phosphodiesterase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020758
InnateDB Gene IDBG-634206 (SMPD1)
Protein Structure
UniProt Annotation
Function Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol (By similarity). {ECO:0000250}.
Subcellular Localization Lysosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006685 sphingomyelin catabolic process
GO:0008152 metabolic process
GO:0023021 termination of signal transduction
GO:0035307 positive regulation of protein dephosphorylation
GO:0043407 negative regulation of MAP kinase activity
GO:0046513 ceramide biosynthetic process
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR004843 Calcineurin-like phosphoesterase domain, apaH type
IPR008139 Saposin B
IPR011001 Saposin-like
IPR011160 Sphingomyelin phosphodiesterase
IPR029052 Metallo-dependent phosphatase-like
PFAM PF00149
PRINTS
PIRSF PIRSF000948
SMART SM00741
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VD19
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505097
UniGene Bt.7951
RefSeq NP_001068655
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119881
GenPept AAI19882

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca