Version 5.4
Bos taurus Protein: RWDD3
Summary
InnateDB Protein IDBP-688265.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RWDD3
Protein Name RWD domain-containing protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028701
InnateDB Gene IDBG-636348 (RWDD3)
Protein Structure
UniProt Annotation
Function Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Cytoplasm. Note=Colocalizes with UBC9/UBE2I in nuclear spots. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0033235 positive regulation of protein sumoylation
GO:1902073 positive regulation of hypoxia-inducible factor-1alpha signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR006575 RWD domain
IPR010541 Domain of unknown function DUF1115
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF05773
PF06544
PRINTS
PIRSF
SMART SM00591
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A3KN24
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 614557
UniGene Bt.22304
RefSeq NP_001091597
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133512
GenPept AAI33513

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca