Version 5.4
| Bos taurus Protein: SEC14L2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-688319.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | SEC14L2 | ||||||||
| Protein Name | SEC14-like protein 2 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000051657 | ||||||||
| InnateDB Gene | IDBG-636396 (SEC14L2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol. {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001071
Cellular retinaldehyde binding/alpha-tocopherol transport IPR001251 CRAL-TRIO domain IPR009038 GOLD IPR011074 CRAL/TRIO, N-terminal domain |
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| PFAM |
PF00650
PF13716 PF01105 PF13897 PF03765 |
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| PRINTS |
PR00180
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| PIRSF | |||||||||
| SMART |
SM00516
SM01100 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P58875 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 282469 | ||||||||
| UniGene | Bt.44611 | ||||||||
| RefSeq | NP_808812 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF432353 AF487977 BC109891 | ||||||||
| GenPept | AAI09892 AAL90886 AAO31942 | ||||||||