InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SCLY

Summary

InnateDB Protein

IDBP-694637.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCLY

Protein Name

Selenocysteine lyase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013719

InnateDB Gene

IDBG-642202 (SCLY)

Protein Structure

UniProt Annotation

Function

Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0009000	selenocysteine lyase activity
GO:0016740	transferase activity
GO:0016829	lyase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001887	selenium compound metabolic process
GO:0006629	lipid metabolic process
GO:0008152	metabolic process
GO:0032868	response to insulin
GO:1900408	negative regulation of cellular response to oxidative stress

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000192 Aminotransferase class V domain
IPR015424 Pyridoxal phosphate-dependent transferase
IPR016454 Cysteine desulfurase, NifS

PFAM

PF00266

PRINTS

PIRSF

PIRSF005572

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2VDS1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

790815

UniGene

Bt.9081

RefSeq

NP_001077273

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC133375

GenPept

AAI33376