Version 5.4
Bos taurus Protein: FOXP1
Summary
InnateDB Protein IDBP-697653.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXP1
Protein Name Forkhead box protein P1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000021993
InnateDB Gene IDBG-644975 (FOXP1)
Protein Structure
UniProt Annotation
Function Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002329 pre-B cell differentiation
GO:0002639 positive regulation of immunoglobulin production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0030324 lung development
GO:0033152 immunoglobulin V(D)J recombination
GO:0045214 sarcomere organization
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048745 smooth muscle tissue development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0055007 cardiac muscle cell differentiation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0061140 lung secretory cell differentiation
GO:0072358 cardiovascular system development
GO:1901249 regulation of lung goblet cell differentiation
GO:1901250 negative regulation of lung goblet cell differentiation
GO:2000727 positive regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001766 Transcription factor, fork head
PFAM PF00250
PRINTS PR00053
PIRSF
SMART SM00339
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4IFD2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515903
UniGene Bt.17953
RefSeq NP_001077158
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134525
GenPept AAI34526

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca